“Space Elevators” to be Constructed as Part of the Technobrain Competition to be Held at Technion

Yuri Artsutanov, the Leningrad engineer who developed the idea of the ​​”space elevator,” will travel from Russia to Israel especially to judge the competition; among the competitors this year – three father-and-son teams of Technion graduates and students

Yuri Artsutanov, the engineer who developed the concept of the “space elevator,” will be the guest of honor and one of the judges in the traditional Technobrain Competition to be held at the Technion on June 18 as part of the Board of Governors meeting. Among the competitors this year – three father-and-son teams of Technion graduates (fathers) and students (sons).

techno2The concept of the “space elevator” first appeared in 1895 when a Russian scientist by the name of Konstantin Tsiolkovsky, inspired by the newly constructed Eifel Tower in Paris, thought of a tower that reached all the way into space. In 1957 Yuri Artsutanov drew up a more feasible plan for building such a space tower. He proposed using a geostationary satellite as a base from which to build it. He suggested lowering a cable toward Earth while a counterweight was extended from Earth, keeping the cable’s center of gravity at the geosynchronous point. Artsutanov published his ideas in the Sunday supplement Komsomolskaya Pravda (a national newspaper) in 1960.

The challenge of this year’s Technobrain is to build a device capable of climbing in a nearly vertical manner (at an 80 degree angle to the ground), to a height of 25 meters (for this purpose the Technion has ordered a huge crane), and then slide down from this height while lifting a “space elevator” carrying practical cargo from the other side of the pulley (the position of the pulley will signify the location of the Space Station in space, while the mission course will emulate  the movement of the space elevator).

Contestants will not be allowed to use energy sources of combustion or open flame of any kind. In addition, at the height of 12.5-17 meters, competing devices will release a flag or other visual signal to mark the point of no return.

Winners of the competition will be awarded 5,000 and 3,000 NIS cash prizes.

The Technobrain Competition is in its twelfth year, in memory of its promoter and founder Neev-Ya Durban, a student and outstanding Technion graduate. Neev-Ya was serving as an officer in the IDF when he was murdered during a mugging on a quiet street in Tel-Aviv in March 2003. The competition and the prizes are funded by Dr. Robert Shillman (who everyone knows as “Dr. Bob”), who did his graduate work at the Technion. Yuri Artsutanov’s visit to the Technion is supported through the Dean of Students Office, the Asher Space Research Institute (ASRI), and the foundation founded by family members of Norman and Helen Asher from Chicago.

Professor Peyman Milanfar from the University of California Santa Cruz, at the Technion Conference:

To improve the quality of digital photography in small cameras it will be necessary to take a number of pictures and merge them together into one good image – Google Glass are the first to do so.

“Those of you with a keen eye and even those of you without can distinguish between a photo taken with a high quality camera than from one taken with a cell phone, but this will not be the case for long,” asserted Professor Peyman Milanfar from the University of California Santa Cruz, an expert in image processing and artificial vision who has been working for Google over the past year. He spoke at the Fourth Annual International Conference held by TCE Technion Computer Engineering Center named after Henry Taub at the Technion. Professor Milanfar is working with the team developing the Google Glass software.

Professor Oded Shmueli, the Technion’s Executive Vice President for Research, said at the opening of the conference: “We are at the brink of a process which will usher in a new era. The areas of research discussed at the conference, such as artificial intelligence, computer vision and image processing, affect all aspects of our lives.

Within a decade from now cars will travel on roads equipped with computer, sensors and navigation and radar systems which will allow them to travel alone without the intervention of a driver.”

Prof. Oded Shmueli

Prof. Oded Shmueli

The TCE Technion Computer Engineering Center was inaugurated three years ago and since then has become a leading center of excellence in groundbreaking research,” said Professor Assaf Schuster, the Head of TCE. “We have been successful at creating here a new model for collaboration between academia and industry.”

According to Professor Milanfar it will be hard and nearly impossible to achieve the level of next generation camera with the simple cameras installed today in cellular phones and tablets, and which in the near future may also be used as part of wearable computing devices. It is because they lack all the moving parts and the complex heavy lenses that professional cameras have. Even the need of not overburdening the user, which has prompted planners to make them lighter and smaller, doesn’t let them compete with the big cameras without encountering physical limitations. The

Professor Peyman Milanfar wearing the Google Glass

Professor Peyman Milanfar wearing the Google Glass

miniaturization of devices makes it very difficult to bring light into the device, so what remains is to use sophisticated algorithms to compensate for the size reduction.

“My job at Google is to develop the field of computerized photography that can merge a number of former disciplines such as image processing, photography, computer graphics and computer vision. It includes the development of algorithms, hardware Optics and image processing techniques (Rendering),” explained Professor Milanfar. “The principle is quite simple – instead of taking only one image you shoot a series of images and then merge them together into one image. This can be in the form of a high resolution picture, a trivial feature that allows intensified use of multiple photos, or making use of other ‘tricks’ such as shooting several pictures from different angles and calculating the distance to objects, so that you will be able to decide in which area of the picture to focus and what part of the image will remain vague to achieve a sense of depth. Another ‘trick’ that can be used is to capture images that cannot be detected by the naked eye, such as night vision (by using infra-red sensors),and the ability to detect changes that occur very quickly or very slowly, distinguishing fine details (for example, the motion of a baby’s breathing through cameras installed in a child’s bedroom).”

Scientists (and high school students alike) that use microscopes are surely aware of the phenomenon that occurs when looking at a sample – where only the central portion of the image appears very sharp while the rest of it remains vague. Merging the images will produce one photo where all of the parts of the specimen are sharp and clear. “Google Glass is the first device that contains a camera that at every snapshot photographs a series of pictures and merges them,” added Professor Milanfar.

Professor Amnon Shashua from the Hebrew University in Jerusalem, Co-founder, Chairman of the Board and CTO of Mobileye and the startup company OrCam, described another approach to wearable computing based cameras. OrCam developed a system that includes a camera and microphone that fasten onto regular eyeglasses. The system allows the visually impaired to point at bobjects such as street signs, traffic lights, buses or restaurant menus, and reads it back to them (the menu, color at traffic light, street sign, etc…).

“The OrCam concept differs from Google Glass – as it doesn’t shoot a photo each time the user requests a picture but rather shoots a continuous video and performs immediate processing. This requires a completely different deployment in terms of hardware and particularly with regards to energy consumption,” said Professor Shashua.

PTC signed an agreement with the Technion to establish a center for robotics and digital content

The agreement includes the option to expand the cooperation in the future to include the Technion institutions in the USA and China

The scope of the investment is 7 million dollars

X May, 2014 PTC Inc. signed an agreement with the Technion to support the establishment of a center for robotics and digital content in the department of Education in Science and Technology, investing 7 million dollars. Within the framework of this agreement, PTC will finance the creation of the center and its operational costs for the first 3 years. PTC has been operating in Israel for over 20 years. The Israeli branch is one of 3 worldwide development centers. PTC employees will take part in various activities of the Robotics Center. In addition, PTC will make its software available to Technion students in the new center. Both sides favorably view the possibility to expand the cooperation and include Technion institutions in the US and China.

PTC Inc. is an American company based in Boston (Needham, MA) and traded on the NASDAQ. The company has over 6,000 employees and sales in 2013 of a billion and three hundred million dollars. PTC customers are some of the largest manufacturers in the world, including: Toyota, Lockheed Martin, Boeing, Audi, Caterpillar, General Electric, Raytheon, EADS, Samsung, Dell, Toshiba, Motorola, and more.

PTC’s office in Israel was established in 1991 as the first development center outside of the US. Today this development center employs about 250 professionals in Haifa and Herzliya. Outside of the US, it is the second largest PTC development center in the world. In recent years, PTC has named the Israeli office a strategic development center and as a result the office has tripled in size in less than a decade. The Israel office is responsible for developing PTC’s leading products that are sold worldwide.

With PTC’s software clients can design products in 3D. They can manage all aspects of the product life cycle starting with concept and design and ending with production and support. The software allows PTC’s clients to digitally design the product, visualize it in three dimensions, and examine how each of its components fit together. Clients and vendors can test the product during the design and easily modify it before going to production.

Ziv Belfer, Manager of the PTC Israel development center states: “We are excited about signing the agreement with the Technion and about taking part in the establishment of the new center. As a company that develops new technologies, we value technological education. The Technion is considered one of the leading academic institutions in the fields

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of engineering and technology and such cooperation is another step in the advancement of technological education in Israel and abroad.”

Prof. Boaz Golani, Vice President for External Relations and Resource Development at the Technion, stated that: “The Technion welcomes partnerships with technology companies that enrich the curriculum and contribute to the students learning experience. The agreement is a further step in an extensive range of existing connections between the Technion and educational institutions in the State of Massachusetts. PTC’s contribution is yet another evidence for the Technion’s reputation and international recognition as one of the leading institutions in the world in science and technology.”

For more information: Idit Rosenberg, Media-PR, 052-8527125

Mechanism that Expels Damaged Proteins “Takes a Break” Under Stress

Proteasomes temporarily stop working until oxidative stress dissipates

Researchers at the Technion-Israel Institute of Technology have discovered that the proteasome – the “biological machine” found in each and every one of the body’s cells (and the mechanism by which the body disposes of damaged proteins) – “takes a break” when cells are under harmful oxidative stress. The findings are published this week in Cell Reports.

The team led by Prof. Michael Glickman, of the Technion Faculty of Biology compares the phenomenon to a person caught in a sandstorm closing their eyes until the storm passes to avoid damage.  They found that even after severe damage (which normally can kill cells), proteasomes get back to work properly, as long as the damage is temporary.

Potential damage to cells comes from a long list of sources, including harmful oxidation that can arise as a side effect of the body’s natural energy production.  Such free radicals (reactive oxidative species) attack the body – including the proteins that make up a large portion of human solid body mass.  Resulting damaged proteins must be disposed of quickly, or they will accumulate and cause long-term damage.

Proteasomes remove damaged proteins by recycling them into new proteins. The paradox is that proteasomes themselves are made up of proteins, something that led the researchers to ask: how do proteasomes avoid oxidative stress damage?glikman

“In our experiments, the proteasomes stop working for up to 3 hours during times of stress, with very minor deleterious outcome,” said Prof. Glickman. “In this way, by shielding the protein-recycling mechanism, it reduces potential self-damage during an episode of oxidative stress, and in turn, protects the body from cumulative or unpredictable damage. After such a break, there is a good chance that oxidative stress has passed on, at which time the proteasome can get back to cleaning up the mess left behind.”

The research was conducted as part of Nurit Livnat-Levanon’s doctoral thesis, in collaboration with Noa Reis, microbiologist and lab manager together with Prof Thorsten Hoppe their partner on a Deutsch-Israelische Projektkooperation (DIP) grant at the University of Cologne, Germany.

In the photo: Prof. Michael Glickman. Photographed by: The Technion’s Spokesperson’s Office

According to Professor Guillermo Sapiro, a Global Expert on Image Processing and the Lead Speaker at the Technion Computer Engineering (TCE) Conference to be held at the Technion:

“The field of image processing is opening doors to many other new global applications – like computing tools for early diagnosis of psychiatric disorders”

“Perhaps in the future we can provide computational tools for early diagnosis of psychiatric disorders,” says Professor Guillermo Sapiro, from Duke University in the US, who will be the lead speaker at the Fourth Annual International TCE Conference that will be held at the Technion on May 26-27.

Professor Sapiro is a world expert in image processing who holds numerous technological breakthroughs in the field of video processing and image compression techniques, which were used to accelerate the speed of image broadcasts from Mars to Earth and are being used in the development of new vaccines based on photographic imaging of a virus.

“Along with psychiatrists Helen Egger and Geri Dawson I am working on the development of computational tools for early diagnosis of psychiatric disorders through video imaging analysis,” says Professor Sapiro. “Today, early diagnosis and support in the realm of mental health are limited to privileged kids. Our idea is to develop screening techniques that are both short and easy to administer, that can be given at school, home and pediatric clinics, what will enable access to appropriate mental health diagnosis and help to the general population. We believe that mental health screening should be standardized, like hearing tests are today. One of our main goals is to make tools available, consented to by caregivers, for very early screening of mental health, and one which will enable the system to be able to provide referrals for a child to be seen by a specialist where needed – just as standardized hearing tests given at schools serve as a basis from which children get referred to a specialist. We want mental health to be at the same level. In the US for example, less than one fifth of children undergo proper mental health diagnosis, such as in Autism or anxiety disorders where diagnosis is often provided in a 3-4 year delay on average in comparison to what we are proposing. Early screening therefore should not be limited to privileged children. We want to incorporate the technology we are developing into simple to use devices.”

Professor Guillermo Sapiro, a Global Expert on Image Processing and the Lead Speaker at the Technion Computer Engineering (TCE) Conference to be held at the Technion

Professor Guillermo Sapiro, a Global Expert on Image Processing and the Lead Speaker at the Technion Computer Engineering (TCE) Conference to be held at the Technion

Born in Uruguay, Professor Sapiro immigrated to Israel in the late 1980s as a kibbutz volunteer, and in 1989 was accepted to the Faculty of Electrical Engineering at the Technion. “I wanted to do my undergraduate degree at an excellent institution and of course the Technion was an obvious choice,” he said.

“I enjoyed my undergraduate degree so much that continuing on to graduate studies at the Technion came naturally. We worked very hard, much harder than what I have observed later at other universities, but it was fun. The Technion shaped my life and my career, and whenever I visit the Technion I feel as if I have come home. I met my best friends at the Technion, and my wife, so you can say it was a perfect package deal.”

Developments in video processing and battery imaging have led to many applications,” adds Professor Sapiro. “I love interdisciplinary research and working with people. I have been very lucky to be collaborating with outstanding colleagues and students who have helped me enter new disciplines. For example, in the technology development for finding new footholds for vaccinations based on tracing the outer contours of the flu virus, I am working with Dr. Sriram Subramaniam , a researcher from the American National Institute of Health (NIH).  The idea for this research is to take information from CT scans and to use very advanced techniques in image processing that we developed to reconstruct the 3D shape of the Env, a protein in the contours/membrane of the HIV virus (we also have results on Influenza). This is imperative to understanding the mechanism of the transmission of the virus across cells.”

“The best decision of my academic career was to choose Professor David Malah from the Technion as my master’s degree advisor, and Professor Allen Tannenbaum from the Technion as my PhD advisor.” He added that, “David and Allen were not only the best mentors a person can wish for, but extraordinary human beings. They have made me into who I am today. I not only learned science from them, but also how to approach research, how to collaborate, how to mentor, and basically every single component of what is needed to be a successful researcher and human being. We have remained good friends and communicate often. Moreover, in my doctoral studies I collaborated with Professor Alfred Bruckstein, from the Faculty of Computer Science at the Technion, and I can’t imagine a better way to complement my academic experience learning than working with him, David and Allen. All three of them instilled in me the joy of learning and discovery. I hope to be able to inspire my students as they encouraged me.”

The 2014 TCE conference will be held at the Technion on May 26-27, and will be attended by world leading researchers in machine learning, signal processing and computerized vision. Participants will include Professor Richard Baraniuk from Rice University, Professor Ronald Coifman from Yale University, Professor Peyman Milanfar from University of California, Santa Cruz, Professor Joachim Weickert from Saarland University in Germany, Professor Guy Gilboa, Professor Nati Srebro and Professor Ronen Talmon from the Technion, Professor Michal Irani from the Weizmann Institute, and Professor Amnon Shashua from the Hebrew University in Jerusalem.

The TCE Conference Program can be found here: http://tinyurl.com/tceprog

 

Within eight years: Student dropout rates have significantly decreased among the Arab population at the Technion – only 12% in comparison with 73%.

The Technion has Launched a New Program for Outstanding Arab Students – a First of its Kind in Israel

 

A significant decrease in the number of student dropouts of Arab descent has been registered at the Technion. Within eight years the percentage went down from 73 to 12. This is what was mentioned at the inauguration of a new program for outstanding students – a first of its kind in Israel.

The Assistant to the Senior Vice President for Minorities, Professor Yosef Jabareen, said that the program was built after it became apparent that Technion activities to lessen the dropout rate of Arab students was successful, and when the percentage of Arab students at the Technion reached the percentage of the general Arab population in Israel. For the time being, it has been decided that this will be an annual program for Arab students who excel in their studies, with the aim to: encourage them to continue on to graduate studies and to provide them with assistance in integrating into the Israeli labor market.

פרופסור סידי מופיעים בפני הסטודנטים המצטיינים. צילום: שרון צור, דוברות הטכניון

פרופסור סידי מופיעים בפני הסטודנטים המצטיינים. צילום: שרון צור, דוברות הטכניון

“When I completed my undergraduate studies at the Faculty of Mechanical Engineering at the Technion, it took me a year to find a job,” related Professor Jabareen to the outstanding students in the audience. “Finally, I found a job as a security guard at the Holon Cemetery. I decided to continue my education and today I’m a faculty member at the Technion.  I believe that you can do it, too!”

A poll conducted among outstanding Arab students revealed that about 56% of them would like to continue on to graduate school. Most of them want to get a better understand of the business world and expressed interest in entrepreneurship. Many also wanted to improve their command of English and Hebrew.

The new program, “Generous Hands” (in Hebrew Yad Nadiv) was designed in accordance with the survey findings, and in collaboration with the Budget and Planning Committee (PBC) sub-committee of the Council for Higher Education. Outstanding students will participate in special workshops, be sent on tours of leading laboratories abroad, and will be given scholarships. A special grant will be given to lecturers that will accompany them.

Professor Hossam Haick from the Faculty of Chemical Engineering told students that,  “For many years the Arab community concerned itself with survival, since we didn’t have a lot of opportunities. Today we understand that excellence is the key to breaking down barriers.”

“Every employer thinks of how to advance his/her business and to this end seeks to hire the best and most outstanding. From my experience, excellence is not an easy feat – it involves perseverance, dedication and an ability to deal with failures. To succeed we also must know how to handle failure. In the future, when you are a success, remember how much support you received from the Technion and give back to the community.”

Sara Katzir, the Head of the Beatrice Weston Unit for the Advancement of Students at the Dean of Students Office said, “Today we are embarking on a new path, now that we have managed to narrow down the dropout rate. You are among the first in Israel to participate in this new program, and many eyes are fixed on you.”

In the photo: Professors Yosef Jabareen and Moshe Sidi, Technion’s Senior Executive Vice President, appearing before the outstanding students at the inauguration ceremony.

Photographed by: Sharon Tzur, the Technion’s Spokesperson’s Office


“Pharmacological Trojan Horse” Fighting Cancer and Resistance to Anticancer Drugs

Technion researchers develop a novel approach for potential treatment of cancer cells that are resistant to chemotherapy

Technion researchers have discovered that multidrug resistant cancer cells frequently produce a large number of lysosomes. Taking advantage of this unique feature of the production of multiple lysosomes and the dramatic irreversible accumulation of certain lipid-soluble drugs bearing light-sensitive properties in these lysosomes– a “Pharmacological Trojan Horse” has been developed  that results in the destruction of drug resistant cancer cells.

For this groundbreaking research achievement, Professor Yehuda Assaraf, the Dean of the Faculty of Biology, will be awarded the Hilda and Hershel Rich Innovation and Entrepreneurship award in June 2014. This innovative new technology has been registered as an American patent, and has stirred a great deal of interest among major international pharmaceutical companies. Its potential therapeutic approach was published in the journal “Cell Death and Disease” and received wide coverage in a “Spotlight of Cell Press” article.

Yehuda G  Assaraf“Cancer cells acquire a wide range of sophisticated mechanisms to overcome cytotoxic drug therapy (i.e. chemotherapy) directed against them,” explains Professor Assaraf. “This phenomenon, known as ‘multidrug resistance’ (MDR) often stems from the fact that cancer cells possess an abundance of pump proteins, located in the membrane of cancer cells, that act as efficient pumps which expel a multitude of anticancer drugs from the cancer cells. This is an important mechanism by which malignant tumors become resistant to chemotherapy.”

Two types of MDR are known– inherent drug resistance that exists prior to drug therapy as well as acquired drug resistance that is provoked by drug treatment. Therefore, Professor Assaraf and members in his research team, including Dr. Michal Stark, Dr. Eran Bram and Yamit Adar, made it their primary goal to develop innovative therapeutic strategies in order to overcome the MDR phenomenon, which is a major hindrance to the development of curative drug therapies of cancer.

The researchers searched for the “Heel of Achilles” of MDR cancer cells which would constitute the weakest point through which these chemoresistant cancer cells could be defeated. They discovered that MDR cancer cells often contain a large number of microscopic intracellular organelles called lysosomes. Lysosomes were first discovered in 1974 by Nobel Laureate, Professor Christian de Duve. Lysosomes are intracellular acidic vesicles that contain dozens of hydrolytic enzymes capable of breaking down virtually all kinds of cell components, including proteins, fats, sugars, DNA and RNA. The role of lysosomes is to break down these cell components and other cells that have reached their end, to safeguard the proper physiological functioning of body cells.

The researchers discovered that light-sensitive, lipid-soluble drugs bearing weak basic features, selectively concentrate to very high levels within the multiple lysosomes present in MDR cancer cells. “MDR cancer cells are frequently equipped with two complementary defense systems,” explains Professor Assaraf. “One is the drug extrusion pump proteins located in the cell membrane that efficiently expels different anticancer drugs. The other is the multiplication of lysosomes; many anticancer drugs are lipid-soluble drugs with attributes bearing weak basic features. In other words, in an acidic environment such as inside lysosomes, these drugs become positively charged, get irreversible captured by lysosomes and accumulate to very high concentrations. Drugs capable of escaping one of the “guardians”- that is – the pumps that expel anticancer drugs, will be efficiently “vacuum-cleaned” by the numerous lysosomes found in the resistant cells and thereby prevent the drug from damaging its targeted site in the cancerous cell, resulting in high drug resistance.”

“We took advantage of this unique feature as an “Achilles Heel” and devised a “Pharmacological Trojan Horse” to kill MDR cancer cells,” explains Professor Assaraf. “When we illuminated light upon the MDR cells containing the light-sensitive drugs trapped in the lysosomes, it created oxygen free radicals that destroyed the lysosome membrane and as a result, all of the contents of the lysosomes was spilled into the cancerous cell. This resulted in a massive release of the above enzymes, and rapid digestion and destruction of MDR cancer cells.”

In collaborative efforts with other researchers, among them Professor Griffioen, Dr. Nowak-Sliwinska, Professor van den Bergh, Professor Skladanowski, and Professor Sarna from Holland, Switzerland and Poland, it turned out that in live model experiments using multidrug resistant tumors of human ovarian cancer origin, the core of the tumor was destroyed upon exposure to light, after having accumulated vast amounts of anticancer drugs inside the lysosomes. Moreover, due to the free oxygen radicals that were created after light exposure, the blood vessels nourishing the tumor were destroyed and others were occluded (i.e. blocked). As a result, the blood supply to the remaining cells in the malignant tumor was cut off, and this led to the destruction of any malignant cells that remained.

Professor Assaraf and his research team are diligently working towards developing a second generation of “Pharmaceutical Trojan Horse” selectively targeting cancer cells only by homing protein receptors that are selectively present on the malignant cells without harming healthy body cells. These receptors will deliver the “Pharmacological Trojan Horse” into the lysosomes, which will then be activated by light irradiation from optic fibers. This and much more – the researchers are also developing an alternative “Trojan Horse” that will be activated by ultrasonic waves that would be possible to target any cancerous tissue or metastasis of cancerous cells in a patient’s body without using any invasive procedure.

However, Professor Assaraf emphasizes that the way to develop a “Pharmacological Trojan Horse” for the practical treatment of malignant tumors in humans is still a long way off.

 image01

In the image: MDR lung cancer cells containing large amounts of lysosomes (vesicles marked in red) shown on the bottom line of resistant cells as compared with the top line showing sensitive cancer cells with small amounts of intracellular lysosomes). The green fluorescent drugs which are sensitive to light accumulate to very high concentrations in the multiple lysosomes in multidrug resistant tumor cells (the vesicles marked in green) and after exposure to light the multiple lysosomes explode due to the abrupt formation of oxygen free radicals, and the lysosomes enzymes become released into the cells, hence digesting the contents of the cancer cells and killing them.

Scientists, Doctors and Patients Convene at a Unique Meeting Aimed at Developing New Psychiatric Treatments

“Research in this field is facing significant challenges, and we need to initiate new ways to deal with it and develop other areas such as early intervention and new treatments.

The goal: improved quality of life and enhancing the capabilities of the mentally ill”; “Sleep disorders can impair the functioning of stem cells in the immune system”

Scientists, doctors and patients will come together at a unique meeting in Australia this week, aimed at developing new treatments for psychiatric illness and brain diseases that affect the mind and cognition. Two Technion researchers will participate at this special forum ‘Meeting for Minds,’ Assistant Professors Asya Rolls and Itamar Kahn. The conference was organized in collaboration with the Technion Society of Australia (TSA).

פרופסור משנה איתמר קהאן. צילום: דוברות הטכניון

פרופסור משנה איתמר קהאן. צילום: דוברות הטכניון

In recent years, more and more studies on brain imaging are being conducted on people with mental illnesses who suffer from emotional (such as depression and anxiety), cognitive (such as autism and attention deficit disorders) and perceptual (schizophrenia) disorders. The goal is to amass significant data on brain structure and function of thousands of healthy and non-healthy individuals in the hope to gain new insights into these disorders (its occurrence, severity and development). Imaging data is collected from fetuses, infants, teenagers, adults and the elderly. In the context of psychiatric and mental disorders, the challenge is to collect information in the early stages of the disorder appearing in at-risk groups or right at the onset in patient groups, and to consider environmental factors known to have critical importance in mental illnesses.

“Mental and psychiatric disorders present significant challenges, since the source of the disturbance may be connected to biological processes and environmental factors taking effect already at the embryonic stage, in childhood or adolescence, many years before the disorder is manifested. Hence there is a need for imaging over many years and across diverse populations,” said Assistant Professor Itamar Kahn from the Rappaport Faculty of Medicine at the Technion. “The adoption of long term brain imaging over a wide population, along with the attempt to identify risk factors over many years before the onset of the syndrome, gives us a broader understanding of psychiatric disorders and mental health so that we may be able to lessen or prevent the disorder or possibly predict a reaction to a specific treatment.”

Prof. Asya Rolls

Assist. Prof. Asya Rolls

“At the conference I would like to promote discussions on the effects of mental health on one’s physical immunity and particularly on the functioning of our immune system,” said Assistant Professor Asya Rolls. “Our laboratory focuses on how the mind influences our immune functions. For example, we can see that sleeping disorders can impair the functioning of stem cells in the immune system. Emotions can also affect the immune system; for example, negative emotions such as stress and mental strain can affect our ability to cope with an illness. On the other hand, positive emotions such as an expectation that a new drug will provide a cure are known to have positive effects on one’s physical condition, recognized as the placebo effect. I will try to promote the importance and need for research that combines the two disciplines, the brain and the immune system, in order to better understand the neurological mechanisms that link the brain and the immune system.”

To achieve significant progress in the medical aspects of this issue requires collaboration between basic scientists as physician-scientists from different disciplines. The ‘Meeting for Minds’ forum is taking it one step further – by involving patients and their families in discussions on research directions. “From my point of view this is a significant step, because in order to advance we need active participation in studies lasting over many years,” added Assistant Professor Kahn.

In the photo: Assistant Professor Itamar Kahn

Minister of Education, Rabbi Shai Piron notified and congratulated Technion Faculty of Physics Distinguished Professor Mordechai (Moti) Segev upon being selected as the 2014 Israel Prize winner for research in chemistry and physics.

The award committee’s reasoning stated that, “Professor Segev is a ground-breaking physicist in the field of optics and lasers. His pioneering contributions are sources of inspiration and his scientific work is referenced in thousands of scientific articles.”

Technion President, Professor Perez Lavie, congratulated Distinguished Professor Segev and thanked him for the great honor he has brought to Technion.

In the Speed of Light

segev_siteWhen the master of ceremony called out his name, Professor Mordechai (Moti) Segev approached the stage wearing jeans and a white shirt.  He hopped over the stair easily and to the sounds of laughter from the audience that filled the congress hall in Munich, he received the prestigious European Physics Society (EPS) Quantum Electronics Award in 2007.

Back in the nineties and early 2000, Professor Moti Segev from the Faculty of Physics studied the behavior of solitons – wave packets that behave and interact with one another like particles do: attracting, repelling, etc. Since then Moti Segev has gone into other areas, ranging from photonic lattices and waves’ propagation in random media to optofluidics – where light controls the mechanical properties of a fluid, and more recently into sub-wavelength imaging. He has made profound discoveries and started several new areas.

Professor Segev and his research group from the Faculty of Physics use non-linear optics to study the basic phenomenon taking place within the realm of non-linear physics. Over the past decade, Professor Moti Segev and his research partners published five articles in the prestigious scientific journal, “Nature” and many  articles in Science magazine, Nature Physics, Nature Photonics, nature Materials, and the premiere physics journal Physical Review Letters.

Moti Segev (formerly Sakajo) was born in Romania. When he was three years old his family made an Aliyah to Israel.

They settled in Haifa, in the Stanton neighbourhood in the lower tier of the Carmel city, a poverty-stricken part of town. When he was six, evacuations began, and the family was relocated in ‘improved housing units’ in the Neve Sha’anan neighbourhood (on the outskirts of Technion City).

Young Moti excelled in his studies from day one. During the summer vacation between Grades 1 and 2, he experimented in the field near his house, with limestone wrapped around stone. The result was astounding! Four fire trucks were needed to put out the fire while Moti hid under his parents bed, Shlomo and Zelda.

The family didn`t have money for most things, but for books there always was. Nitsa Movshovitz-Hadar, who later became a professor at the Technion, was Moti`s mathematics teacher. She was the first to recognize his many talents and sent him to extracurricular programs for gifted students at the Technion when he was in 7th Grade.

Despite his outstanding achievements, Moti was suspended from the Municipal Ironi Gimmel High School at 10th grade. The school’s guidance counsellor at the time, Bruria Zafrir, took him under her wing and pledged that from now on he will be manageable.  “School bored me,” he admits. “All that interested me was basketball, the youth movement (Hashomer Hatzair) and girls.”

In the army he was in the flight academy course. He lasted in the course about 14 months, until he flew over the border with Jordan in the training jet the “Fouga Magister.” He was suspended from the course and returned to the Nahal  core, a unit which later entered Lebanon in Operation Litani. He never returned to his flight course. He was discharged from the Army as a lieutenant, and in the reserves he became the commander of a patrol (“siur”) company. His deputy officer was Yair Mordechai from Kibbutz Shluchot  in the Beit Shean Valley. In October 2001, Yair chanced upon a Palestinian on his way home to his Kibbutz. He began to question him, and then the terrorist activated his explosives belt and Yair exploded with him. When Professor Segev tells the story he finds it hard to hide his emotions.

Moti was accepted to the Technion’s Faculty of Electrical Engineering, and completed his undergraduate degree after seven semesters and 250 reserve duty days. For all of the reserve duty he performed during his studies he was eligible for a tuition free ninth semester but he didn’t even need an eighth semester. In addition to the many days he devoted to reserve duty, Moti worked throughout his studies as a youth counselor for children living in fringe neighborhoods such as Tirat HaCarmel, as a teaching assistant in the Faculty of Mathematics, and as an Israeli tour guide. He was very busy and still managed to make the Dean’s list (cum laude). He continued on a direct doctoral study track in electrical engineering, married Tal, and the young couple had three children, Yair, Tamir and Yaron.

Moti did his postdoctoral research period at Caltech and joined Princeton University, where we went through the ranks from assistant professor to full professor in a record time of 4.5 years, and returned to Israel with his family at the end of 1988. “I returned only out of Zionistic ideals and because I wanted to raise my children in Israel,” he explained. “And I don’t have any regrets,” he added.

Are you happy at the Technion?  

“I really enjoy conducting my research at the Technion, but along with this I also have a lot of criticisms which I don’t try to hide.”

Are you the naughty but super talented boy at the Faculty?

Professor Segev laughed and corrects: “No, I’m not the naughty boy. Maybe I am the bad boy who cares deeply for the Technion.”

His students say he is overly demanding, with high expectations from them, almost as high as those he demands from himself, but that on the other hand he is very fatherly and caring, not only in professional related matters but also in personal issues. He has often helped his students find job placements or provided assistance with finding solutions to financial problems. Even the spouses of his students are in contact with him. He currently has ten PhD and masters students and two postdocs. He meets with each of them on a daily basis. Each of his students is working on a different project that is very well defined. Above his office door there is a quote: “Forlorn is the Teacher Whose Students Do Not Surpass Him.”

Professor Moti Segev has no reason to be forlorn. Sixteen of his students are professors at MIT, Princeton, the University of Michigan, the University of Florida, the University of San Francisco, the University of Hamburg and the University of Jena in Germany, the National Taiwan University, the University of Zagreb in Croatia, the University of Rome in Italy, four at the Technion, one at Tel Aviv University and one with Bar Ilan University.

MOTTIGANG

Stealthy “Virtual periscope” sees above-surface/airborne objects from underwater view

Researchers modeled virtual periscope on astronomers’ technology used to counter blurring and distortion caused by layers of atmosphere when viewing stars

–  “Up periscope!” may become a submarine commander’s outdated order, thanks to a team of Technion-Israel Institute of Technology researchers who have developed a new technology for viewing objects above the water’s surface without a periscope poking its head above the waves.  

The technology behind a submerged, “virtual periscope” will be introduced in a presentation at the IEEE International Conference on Computational Photography, held May 2-4, 2014 in Santa Clara, Calif.. (http://www.iccp14.org/)

periscopeAssociate Professor Yoav Y. Schechner, of the Technion Department of Electrical Engineering, and colleagues, developed the virtual periscope called “Stella Maris” (Stellar Marine Refractive Imaging Sensor).  The heart of the underwater imaging system is a camera, a pinhole array to admit light (a thin metal sheet with precise, laser-cut holes), a glass diffuser, and mirrors.   Sunrays are projected through the pinholes to the diffuser, which is imaged by the camera, beside the distorted object of interest.  The latter is then corrected for distortion.

“Raw images taken by a submerged camera are degraded by water-surface waves similarly to degradation of astronomical images by our atmosphere. We borrowed the concept from astronomers who use the Shack-Hartmann astronomical sensor on telescopes to counter blurring and distortion caused by layers of atmosphere,” explains Schechner. “Stella Maris is a novel approach to a virtual periscope as it passively measures water and waves by imaging the refracted sun.”

The unique technology gets around the inevitable distortion caused by the water-surface waves when using a submerged camera

According to Schechner, because of the sharp refractive differences between water and air, random waves at the interface present distortions that are worse than the distortion atmospheric turbulence creates for astronomers peering into space.

“When the water surface is wavy, sun-rays refract according to the waves and project onto the solar image plane,” explains Schechner. “With the pinhole array, we obtain an array of tiny solar images on the diffuser.” When all of the components

work together, the Stella Maris system acts as both a wave sensor to estimate the water surface, and a viewing system to see the above surface image of interest through a computerized, “reconstructed” surface.

The Stella Maris virtual periscope is just the latest technology developed by the researchers, who have also found ways to exploit  “underwater flicker,” i.e., random change of underwater lighting, caused by the water surface wave motion.   Members in the Schechner Hybrid Imaging Lab (http://webee.technion.ac.il/~yoav/lab-and-group/) turned the tables on underwater flicker and used the natural rapid and random motion of the light beams to obtain three-dimensional mapping of the sea floor.

According to the developers, the virtual periscope may have potential uses in addition to submarines, where they could reduce the use of traditional periscopes that have been in use for more than a century.  Submerged on the sea floor, Stella Maris could be useful for marine biology research where and when viewing and imaging both beneath and above the waves simultaneously is important. Stella Maris could, for example, monitor the habits of seabirds as they fly, then plunge into water and capture prey.

“There are many ways to advance the virtual periscope,” says Schechner, who adds that while the system requires sunlight, they are currently working on a way to gather enough light from moonlight or starlight to be able to use the system at night.

Also contributing to this research were current graduate student Marina Alterman and former graduate student Dr. Yohay Swirski (who is now working in industry).  The research was conducted in Prof. Schechner’s Hybrid Imaging Lab in the Technion Department of Electrical Engineering.

https://www.youtube.com/watch?v=ZSh6YSJz_Pk